Welcome to the Lewis Lab
Chromatin orchestrates the regulation of genomic DNA accessibility for gene transcription by integrating a diverse array of biochemical signals.
Our research focuses on elucidating the biochemical mechanisms that establish and maintain silent chromatin, commonly referred to as heterochromatin. Proper maintenance of silent chromatin is essential for preserving cellular identity by ensuring the repression of genes specific to alternative lineages. Disruption of these processes can result in developmental abnormalities or contribute to tumorigenesis.
To investigate these mechanisms, we employ a multidisciplinary approach that integrates highly purified biochemical assays, proteomic and genomic analyses, and genetic screens. Through this work, we aim to advance our understanding of chromatin biology and its implications for development and disease.
